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Unraveling the complex biology of ME and long COVID

Myalgic encephalomyelitis (ME, also known as ME/CFS) and long COVID are highly complex chronic conditions.

Using our AI-led combinatorial analytics, PrecisionLife has undertaken multiple landmark studies in ME and long COVID and identified the first reproducible disease mechanisms and clinically actionable patient subgroups for both conditions.

We've completed the most detailed genetic analysis of ME ever performed, identifying over 250 core genes associated with the disease, revealing clear areas of biological overlap with long COVID, and discovering multiple drug repurposing opportunities with biomarker tests to find the patients who would most likely benefit from them.

With this new level of understanding, we're leading international efforts to bring precision medicine to the diagnosis, treatment, and prevention of these debilitating diseases.

The most detailed genetic analysis of ME-min

Learn more about this foundational research study:

   


Register for the webinar on 5 December

 



LOCOME Project - First Year Review

The final two-year project review is currently being drafted.

LOCOME (Landscape)-min

Read the interim report of the progress made in understanding ME/CFS and long COVID and finding new diagnostic and therapeutic options.



 


 

Further studies

PL MECFS Long COVID - Paper - Reproducibility of Genetic Risk Factors Identified for L

Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries 
Journal of Translational Medicine

PrecisionLife ME-CFS Poster

Genetic Risk Factors for ME/CFS, Long COVID & their Similarities 
Poster and video summary presented at the International Association of CFS/ME Research and Clinical Conference 2025.

Read the paper Open the poster

 

 

PrecisionLife Paper - Genetic Risk Factors for ME-CFS

Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis
Journal of Translational Medicine

PrecisionLife Paper - Genetic Risk Factors for Long COVID-1

Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis
Journal of Translational Medicine

Read the paper Read the paper

Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients

Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients
Frontiers in Digital Health

Analysis of Genetic Host Response Risk Factors in Severe COVID-19 Patients

Analysis of Genetic Host Response Risk Factors in Severe COVID-19 Patients
MedRxiv

Read the paper

Read the paper

 


Video presentations

MECFS Research Roadmap Webinar 400 x 300 px-1


Genomics and Genetic Susceptibilities of ME
Presented at the NIH ME/CFS Research Roadmap Webinar 2024

Video thumbnail - U2F2024

Precision Medicine for Long COVID and ME/CFS
Presented at the Unite to Fight ME Conference 2024

Watch the video Watch the video

 

Video thumbnail - IIMEC2024


The Causal Biology of ME
Presented at the Invest in ME Research Congress 2024

 
Watch the video  

 

 


Blogs

 

Long COVID blog img-min

How new research confirmed long COVID genetic associations for diagnostics and treatments

MECFS blog img-min

New Study Links 14 Genes to ME/CFS
By Simon McGrath for the ME/CFS Research Review

Read more Read more


Partners

MECFS long COVID partners (1)


Datasets

MECFS long COVID data partners-min

Find out more

Contact us